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Appl Environ Microbiol. 1965 March; 13(2): 190-193
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Effects of Minerals on Neomycin Production by Streptomyces fradiae

Department of Biochemistry, University College of Science, Calcutta University, Calcutta, India

ABSTRACT

A study was made on the mineral requirements of Streptomyces fradiae strain 3535 for neomycin production. It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.8, 1.0, and 0.115 µg, respectively. K₂HPO₄ was required at a concentration of 0.1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect. High doses of Zn (0.23 µg/ml or above) caused destruction of neomycin after the fifth day of fermentation.