This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shirato, S. Articles by Nagatsu, C. Search for Related Content PubMed Articles by Shirato, S. Articles by Nagatsu, C. Agricola Articles by Shirato, S. Articles by Nagatsu, C.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1965 September; 13(5): 669-672
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Fermentation Studies with Streptomyces griseus

I. Carbohydrate Sources for the Production of Protease and Streptomycin

2nd Laboratory, Kaken Chemical Co., Ltd., Komagome Kamefujimae-cho, Bunkyo-ku, Tokyo, Japan

ABSTRACT

The effects of four carbon sources and inorganic phosphate on the production of streptomycin and protease by a strain of Streptomyces griseus were studied. Protease production was increased in fermentations with comparatively rapid consumption of carbohydrate, and streptomycin was produced under conditions of moderately slow consumption. Starch was consumed more rapidly than glucose, and, in fermentations with starch as a carbon source, good yields of protease were associated with poor yields of streptomycin. The effect of the concentration of inorganic phosphate varied with the sugar source; the rate of consumption of glucose or fructose increased with the addition of inorganic phosphate, and the utilization of starch or maltose was not affected.