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Appl Environ Microbiol. 1965 September; 13(5): 694-697
Copyright © 1965 American Society for Microbiology. All Rights Reserved.

Some Surface-Active Agents and Their Virucidal Effect on Foot-and-Mouth Disease Virus

Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U.S. Department of Agriculture, Greenport, Long Island, New York

ABSTRACT

Selected cationic and anionic surface-active compounds were tested to determine their virucidal effect on the foot-and-mouth disease virus, type O, strain M11, propagated in primary calf kidney cells. The chemical inactivation of the virus was tested with 0.5, 1.0, 2.0, and 5.0% concentrations of the selected compounds. Virus controls with pH adjusted to cover the expected range of the mixtures of the chemicals and virus were also tested. The absence of virus from the mixtures of chemical and virus after reaction at 28 C for 2 hr was assayed by inoculating suckling mice with the mixtures. One cationic compound, alkyl methyl isoquinilinium chloride, showed considerable antiviral activity due largely to pH effect. The use of the surface-active agents investigated in this study, in the presence of organic material, would not be recommended as virucides.