This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mirocha, C. J. Articles by Nelson, G. H. Search for Related Content PubMed Articles by Mirocha, C. J. Articles by Nelson, G. H. Agricola Articles by Mirocha, C. J. Articles by Nelson, G. H.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1967 May; 15(3): 497-503
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Estrogenic Metabolite Produced by Fusarium graminearum in Stored Corn¹

Institute of Agriculture and College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55101

ABSTRACT

A derivative of resorcinylic acid, produced by the fungus Fusarium graminearum, has been found to be responsible for the estrogenic signs in swine and laboratory rats. An estrogenic response in rats can be incited by injecting intramuscularly as little as 20 µg of the estrogen (F-2). Stimulation in growth of rats was noted at the lower concentrations (20 to 40 µg) of a series. Up to 3,500 ppm of the estrogen was produced on a solid corn medium. The compound is relatively stable to heat and ultraviolet irradiation. Methods of analysis have been developed and include: extraction procedures, evaluations by ultraviolet absorption spectrophotometry, thin-layer chromatography, and gas-liquid chromatography.

¹ Paper No. 6115, Scientific Journal Series, Minnesota Agricultural Experiment Station.