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Appl Environ Microbiol. 1967 May; 15(3): 564-565
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Quantitative Bacteriological Analysis of Sputum as a Test of Antibiotic Efficacy

The Sanatorium Division of the Boston City Hospital, Boston, Massachusetts 18021
Infectious Diease Section, Boston University School of Medicine, Boston, Massachusetts 18021

ABSTRACT

After 5 days of treatment, sputa were analyzed from 40 patients treated with sodium fusidate and 20 patients treated with naficillin. There was a significant decrease in the number of staphylococci, but no significant change in the other flora. The quantitative bacteriological analysis of sputum specimens proved to be a useful laboratory procedure for providing information on the in vivo effectiveness of specific antibacterial therapy in respiratory infections.