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Appl Environ Microbiol. 1967 May; 15(3): 654-656
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Statolon-induced Resistance of Mice to Mengovirus

Biosciences Branch, U.S. Air Force School of Aerospace Medicine, Aerospace Medical Division (AFSC), Brooks Air Force Base, Texas 78235

ABSTRACT

Mice receiving statolon intraperitoneally were 1,000 times more resistant to intraperitoneal challenge with mengovirus than were untreated controls. Protection was afforded when statolon was administered 1 day before or 1 day after intraperitoneal inoculation with the virus. No therapeutic effect was observed when treatment with statolon was delayed for 2 days or more after virus infection. Exposure of mice to a simulated space cabin environment did not increase their susceptibility to the lethal effects of mengovirus infection or eliminate the protective effect of statolon.