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Appl Environ Microbiol. 1967 July; 15(4): 683-689
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Computer Simulation of Fermentation Systems

Institute of Applied Microbiology, University of Tokyo, Tokyo, Japan
Biochemical Engineering Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania 19104

ABSTRACT

Results of batch fermentation of gluconic acid by Pseudomonas ovalis were graphically analyzed to obtain a kinetic model to represent the data. Since gluconic acid was produced by the hydrolysis of a lactone intermediate, the model was necessarily represented by a set of kinetic equations. A computer simulation technique involving the use of the MIDAS program was developed to solve the system of nonlinear equations and to check the appropriateness of the model. Since the maximal specific growth rate and the rate constant for the production of the lactone intermediate varied with time, function generators were used to simulate these system parameters. The merit of using the MIDAS program was considered in relation to analysis and model testing in microbiological processes of similar types.

¹ Present address: Esso Research and Engineering, Florham Park, N.J.