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Appl Environ Microbiol. 1967 July; 15(4): 701-709
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Antifungal Activity of Isothiocyanates and Related Compounds

I. Naturally Occurring Isothiocyanates and Their Analogues

. Drobnica, M. Zemanová, P. Nemec, K. Anto, P. Kristián, A. tullerová, V. Knoppová and P. Nemec Jr.

Department of Microbiology and Biochemistry and Department of Organic Chemistry, Faculty of Chemistry, Slovak Polytechnical University, Bratislava, SSR
Department of Microbiology, Faculty of Natural Sciences, Komensk University, Bratislava, SSR

ABSTRACT

Data are presented concerning the antifungal activity of 11 natural isothiocyanates and 27 synthetized analogues in Aspergillus niger, Penicillium cyclopium, and Rhizopus oryzae, as well as in 13 additional saprophytic and parasitic fungi. A remarkable antifungal activity was observed in some analogues of benzylisothiocyanate and ß-phenylethylisothiocyanate. The latter-mentioned compounds have not been described previously. In the group of benzylisothiocyanates, a correlation, which was inversely proportional, was detected between ED₁₀₀ values for A. niger and R. oryzae and the corresponding molar solubilities of compounds in water. In contradistinction, no relationship was observed between antifungal activity and chemical reactivity of investigated derivatives.