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Appl Environ Microbiol. 1967 July; 15(4): 744-749
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Utilization of Carbon- and Nitrogen-containing Compounds for Neomycin Production by Streptomyces fradiae

Department of Food Technology and Biochemical Engineering, Jadavpur University, Calcutta-32, India

ABSTRACT

A number of carbon and nitrogen compounds were tested for their effect on growth of Streptomyces fradiae 3535 and neomycin production. Dextrin, starch, and maltose were excellent carbon sources for neomycin production, and sodium nitrate, aspartic acid, and glutamic acid were adequate nitrogen sources. Studies on biochemical changes during fermentation in four typical media indicated that there was no direct relation between the growth of the organism and neomycin formation. The pH of the medium might be an important factor for neomycin synthesis. The quantitative formation of neomycin components depended on the variation of carbon and nitrogen sources. On the basis of this study, a suitable synthetic medium for neomycin production has been developed.