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Appl Environ Microbiol. 1967 September; 15(5): 1002-1005
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

LL-A491, A Monazomycin-like Antibiotic

Lederle Laboratories, Division of American Cyanamid Company, Pearl River, New York 10865

ABSTRACT

A new antibiotic, designated LL-A491, was isolated by butanol extraction and crystallization from beers of an unidentified streptomycete, Lederle culture A491. LL-A491 was primarily active against gram-positive bacteria and was related to monazomycin. A tentative molecular formula of C_72±2 H_144±8 O_25±1 N for the antibiotic, based on analyses of the crystalline hydrochloride, picrate, and picrolonate salts, is considerably larger than that proposed for monazomycin, from which LL-A491 was not differentiated by paper chromatography. Analysis of the amorphous polyacetate ester suggested 15 to 16 acetylable groups. Upon hydrolysis, LL-A491 liberated ammonia and a reducing sugar which appeared to be mannose. LL-A491 was dextrorotatory, []_D²⁵ + 14°, and exhibited only end absorption in the ultraviolet region.