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Appl Environ Microbiol. 1967 September; 15(5): 1054-1061
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Agar-Gel Precipitin-Inhibition Test for Coccidioidomycosis

II. Serological Test Antigen Studies in Agar-Gel

Medical Sciences Laboratory and Biological Sciences Laboratory, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

In this study of saprophytic and parasitic growth-phase extracts of Coccidioides immitis, an antigen from the spherule culture supernatant fluid detected a specific antibody in heretofore serologically negative suspect coccidioidomycosis human sera when diffused in agar-gel. This antigen-antibody reaction occurred also in some of the serologically positive human coccidioidomycosis sera. This study indicates that this antigen-antibody reaction should be utilized as a possible routine serological test for complete serodiagnosis.