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Appl Environ Microbiol. 1968 December; 16(12): 1924-1928
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Microbial Content of Nonsterile Therapeutic Agents Containing Natural or Seminatural Active Ingredients

Microbiological Control Laboratories, Sandoz, Ltd., Basel, Switzerland
Control Department of Biochemie, Gmb. H. Kundl, Austria

ABSTRACT

The relationship was investigated between various chemical or pharmaceutical production processes and the extent of microbial contamination, of natural origin, of the resulting products. The products contained active ingredients of vegetable, enzymatic, or animal origin. It was concluded that (i) vegetable products practically free from microbes can be produced if the proper manufacturing steps are taken; (ii) sterilization of the media used to manufacture antibiotics, etc., produces products with little contamination; and (iii) products containing extracts of animal organs require careful refrigeration and addition of preservatives to produce acceptable levels of microbial contamination.