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Appl Environ Microbiol. 1968 February; 16(2): 228-231
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Interaction of Staphylococcal Penicillinase and 6-[D(—)-{alpha}-Guanidino-Phenylacetamido]-Penicillanic Acid

Elizabeth H. Thiele and Harry J. Robinson

Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

ABSTRACT

6[D(—)-{alpha}-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly hydrolyzed by the enzyme.


Appl Environ Microbiol. 1968 February; 16(2): 228-231
Copyright © 1968 American Society for Microbiology. All Rights Reserved.







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