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Appl Environ Microbiol. 1968 March; 16(3): 468-469
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Duration of Prophylactic Effect of Statolon Against Mengovirus in Mice

U.S. Air Force School of Aerospace Medicine, Brooks Air Force Base, Texas 78235

ABSTRACT

Intraperitoneal injection of statolon into mice is known to exert a protective effect against a subsequent infection with a variety of viruses owing to stimulation of production of interferon. To study the duration of such protection, groups of mice were treated with 350 µg of statolon at 69, 55, 41, 27, 13, 6, or 1 day prior to a challenge with mengovirus. Other groups were treated with 760 µg at 1 to 6 days before challenge. Ten days after inoculation with the virus, LD₅₀ determinations were made for each group. Mice which received statolon 1 to 5 days before infection were significantly more resistant to the virus than nontreated controls; no protection could be demonstrated in the other groups.