This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by De Clercq, E. Articles by De Somer, P. Search for Related Content PubMed Articles by De Clercq, E. Articles by De Somer, P. Agricola Articles by De Clercq, E. Articles by De Somer, P.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1968 September; 16(9): 1314-1319
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Effect of Interferon, Polyacrylic Acid, and Polymethacrylic Acid on Tail Lesions in Mice Infected with Vaccinia Virus

Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

ABSTRACT

Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.

¹ Aspirant of the Belgian "National Fonds voor Wetenschappelijk Onderzoek."