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Appl Environ Microbiol. 1968 September; 16(9): 1375-1380
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Electronically Controlled Continuous Culture Device

Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439

ABSTRACT

A photocell-controlled continuous culture device, a Nephelostat, is described that maintains a wide variety of cultures of microorganisms in balanced growth. This Nephelostat controls concentrations of bacteria within ±3% over a cell concentration range of 10⁶ to 10⁹ cells per ml. Growth rates are recorded so that changes in the growth rate are observed over small increments of time. Spontaneous and caffeine-induced mutation rates of two strains of Escherichia coli were compared under Nephelostat and chemostat conditions.