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Appl Environ Microbiol. 1969 February; 17(2): 237-241
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Microbiological Metabolism of Naphthyridines¹

^a Sterling-Winthrop Research Institute, Rensselaer, New York 12144

ABSTRACT

Penicillium adametzi and seven other species convert nalidixic acid, 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, to 1,4-dihydro-1-ethyl-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Forty-seven other species from six orders of fungi seem to achieve the same conversion as judged by chromatographic and spectral evidence. Under special conditions, P. adametzi also produces a second metabolite which was identified as the corresponding 7-carboxylic acid. The metabolic attack on the ring substituent is identical with the pathway previously established with humans. No evidence was obtained for metabolic attack on the naphthyridine nucleus itself.

² Present address: Department of Poultry Science, North Carolina State University, Raleigh, N.C. 27607.

³ Present address: School of Pharmacy, University of Wisconsin, Madison, Wis. 53706.

⁴ Present address: R. J. Reynolds Tobacco Co., Winston-Salem, N.C. 27101.

¹ Portions of this report are taken from U.S. Patent 3,317,401.