This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cimino, J. E. Articles by Tierno, P. M. Search for Related Content PubMed Articles by Cimino, J. E. Articles by Tierno, P. M., Jr. Agricola Articles by Cimino, J. E. Articles by Tierno, P. M.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1969 March; 17(3): 446-448
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Hemodialysis Properties of Clindamycin (7-Chloro-7-Deoxylincomycin)

¹ Hemodialysis Unit, Veterans Administration Hospital, Bronx, New York 10468

ABSTRACT

The effect of hemodialysis (Kolff-type machine) on clindamycin blood levels in anuric patients was studied. At 1 hr after oral ingestion of drug, blood levels ranged from 1.23 to 5.17 µg/ml and fell thereafter. Half-times for peripheral removal were 3.36 µg/ml ± 0.22 when subjects were "off" dialysis and 3.14 µg/ml ± 0.09 during dialysis. Their difference was not statistically significant, indicating that hemodialysis does not affect the blood level of clindamycin. In all studies, significant levels of the antibiotic were present at 12 hr.