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Appl Environ Microbiol. 1969 September; 18(3): 303-306
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Pseudomonas aeruginosa to Carbenicillin and the Combination of Carbenicillin and Gentamicin

Infectious Disease Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
Cincinnati General Hospital, Cincinnati, Ohio 45229

ABSTRACT

One hundred and eleven strains of Pseudomonas aeruginosa isolated from clinical material were studied for susceptibility to carbenicillin. Of the strains, 80% were inhibited by 125 µg/ml or more. The combination of carbenicillin and gentamicin was shown to have inhibitory and bactericidal synergistic effect on 15 of 16 strains of P. aeruginosa tested. There was poor correlation between the single-disc sensitivity method and the tube dilution method.