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Appl Environ Microbiol. 1969 September; 18(3): 337-339
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Reactivity of Two Selected Antigens of Neisseria gonorrhoeae

^a Venereal Disease Research Laboratory, National Communicable Disease Center, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333

ABSTRACT

Two antigen preparations, the soluble antigen and a fraction 1 thereof, isolated in the course of a systematic study of the various antigens of the virulent gonococcus, have been investigated for their ability to serve as antigens for the detection of antibody in patients infected with the gonococcus. The soluble antigen was reactive with 88.2% of the sera from infected females, and fraction 1 was reactive with 71.6% of the sera. Of sera from infected males, only 27.6% reacted with the soluble antigen and only 20.4% with fraction 1. Of sera from individuals presumed free of gonococcal infection, approximately 4% reacted with the soluble antigen; none reacted with fraction 1. This study suggests that these antigens might be adaptable to the detection of human gonococcal antibody, especially in the female.

¹ Present address: Department of Clinical Bacteriology, Regional Hospital, Orebro, Sweden.

² Deceased.