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Appl Environ Microbiol. 1969 September; 18(3): 365-368
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Effects of Topical Anesthetics on Pullularia pullulans and Debaryomyces hansenii

Biochemistry Research Laboratory, Chemistry Department, Roosevelt University, Chicago Illinois 60605

ABSTRACT

The inhibitory effects of three topical anesthetics of various concentrations on the growth of Pullularia pullulans, Debaryomyces hansenii, and on pigment production by P. pullulans were investigated. The topical anesthetics were benoxinate hydrochloride, proparacaine hydrochloride, and tetracaine hydrochloride. In decreasing order, the inhibiting effects of the drugs on growth were benoxinate, tetracaine, and proparacaine for P. pullulans, and tetracaine, benoxinate, and proparacaine for D. hansenii. The pigment formation in P. pullulans was inhibited by the three drugs.