This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Isenberg, H. D. Articles by Siegel, M. Search for Related Content PubMed Articles by Isenberg, H. D. Articles by Siegel, M. Agricola Articles by Isenberg, H. D. Articles by Siegel, M.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1969 September; 18(3): 387-392
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

In Vitro Action of Carbenicillin Against Bacteria Isolated from Clinical Material

¹ Long Island Jewish Medical Center, New Hyde Park, New York 11040

ABSTRACT

More than 500 bacteria isolated from patient material were tested against carbenicillin (disodium -carboxybenzylpenicillin) by diffusion and dilution modalities. The same bacteria, which included Pseudomonas aeruginosa, Escherichia coli, Klebsiella-Aerobacter-Enterobacter group, various species of Proteus, Staphylococcus aureus and epiddermidis, enterococci, pneumococci, Streptococcus pyogenes, etc., were examined for susceptibility to other antibiotics commonly used with special emphasis on ampicillin and cephalothin. The responses of pyocine-typed P. aeruginosa were the most remarkable. The majority of these bacteria displayed susceptibility to carbenicillin by both the dilution and the diffusion techniques. The concentrations of this antibiotic used in the laboratory were of the same order of magnitude as that of the other drugs. The laboratory behavior of the other bacteria, toward this new semisynthetic penicillin derivative approximated their response to ampicillin and cephalothin.