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Appl Environ Microbiol. 1969 October; 18(4): 622-627
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Biosynthesis of Ochratoxin A¹

^a Botany and Plant Pathology Department, Auburn University Agricultural Experiment Station, Auburn, Alabama 36830

ABSTRACT

Biosynthesis of ochratoxin A by Aspergillus ochraceus Wilh. was investigated by radiolabeling experiments in which phenylalanine-1-¹⁴C and sodium acetate-2-¹⁴C were supplied to the fungus in sucrose-yeast extract medium. Results showed that phenylalanine was incorporated unaltered into the phenylalanine moiety of ochratoxin A, whereas the isocoumarin moiety of ochratoxin A was mostly derived via acetate condensation.

¹ Portions of this study were submitted to Auburn University by J. W. Searcy in partial fulfillment of the requirements of the Ph.D. degree.