This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Takatsuki, A. Articles by Misato, T. Search for Related Content PubMed Articles by Takatsuki, A. Articles by Misato, T. Agricola Articles by Takatsuki, A. Articles by Misato, T.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1969 October; 18(4): 660-667
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Antiviral and Antitumor Antibiotics. XX. Effects of Rotenone, Deguelin, and Related Compounds on Animal and Plant Viruses

Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Laboratory of Fungicides, The Institute of Physical and Chemical Research, Yamato-cho, Saitama Prefecture, Japan

ABSTRACT

Rotenoids and related compounds were investigated for their effects on animal and plant viruses. Of 35 compounds examined, rotenone, rotenone norketone, acetylrotenone, acetylrotenone norketone, deguelin, deguelic acid, dehydrodeguelin, and isotubanol norketone, all used at low concentrations, suppressed the growth of Newcastle disease and herpes simplex viruses as determined by the agar diffusion, plaque inhibition method. Most of the compounds likewise decreased the number of necrotic spots on tobacco mosaic virus-infected leaf discs. Only derrisic acid completely inhibited the local lesion formation at subphytotoxic concentrations. Correlation of antiviral activity with respiratory inhibition of these compounds is discussed.