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Appl Environ Microbiol. 1969 December; 18(6): 1050-1056
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Antimicrobial Activity of Some N-Substituted Amides of Long-Chain Fatty Acids

Louisiana State University, Baton Rouge, Louisiana 70803
Southern Regional Research Laboratory, New Orleans, Louisiana 70119

ABSTRACT

Seventy-three N,N-disubstituted amides of long-chain, principally C₁₈, fatty acids were screened for antimicrobial activity against bacteria, yeasts, and molds. Amides containing an epoxy group exhibit a broad spectrum of antimicrobial activity which is further enhanced by unsaturation. Mono-unsaturation alone does not contribute a broad level of activity to the N,N-disubstituted amides of the C₁₈ fatty acids.