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Appl Environ Microbiol. 1970 May; 19(5): 772-775
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Histopathology of Listeria monocytogenes After Oral Feeding to Mice

Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201

ABSTRACT

Ingestion by mice of Listeria monocytogenes in drinking water induced micro-abscesses of the liver and ulcerative enteritis. In pregnant mice, these lesions were larger and more extensive than in nonpregnant female and male mice. Pregnancy is interrupted by a purulent panmetritis and necrotizing placentitis. The early microabscess is unique in that it consists of monocytic cells with bizarre-shaped nuclei. The experimentally induced pathological changes in livers and intestines of mice used in this study are similar to those observed in listeric neonatal septicemia of human infants.