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Appl Environ Microbiol. 1970 July; 20(1): 1-5
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Acquired and Native Resistance of Staphylococcus aureus to Cephalexin and Other ß-Lactam Antibiotics ¹

Section of Infectious and Immunologic Diseases, Department of Internal Medicine, School of Medicine, University of California, Davis, California 95616

ABSTRACT

Staphylococcus aureus cells that are initially susceptible to cephalexin can be induced to acquire intrinsic resistance to cephalexin in comparatively few steps. Concomitantly, resistance to cephalothin, oxacillin, and dicloxacillin increases. By population analysis, there is heteroresistance to cephalexin in some strains of S. aureus. Heterogeneity in colonial morphology on prolonged incubation in the presence of subinhibitory concentrations of cephalexin may constitute an expression of such heteroresistance.

² Visiting Microbiologist for the year 1969 from the Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

¹ Supported by grants AI0-955-01 and AI00384-01 from the National Institute of Allergy and Infectious Diseases and by a grant-in aid from Eli Lilly and Co., Indianapolis, Ind.