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Appl Environ Microbiol. 1970 July; 20(1): 23-25
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Microbial Transformation of 19-Hydroxypregnanes

Kartar Singh, D. J. Marshall and C. Vézina

Departments of Microbiology and Chemistry, Ayerst Research Laboratories, Montreal, Quebec, Canada

ABSTRACT

Nocardia species aromatized 19-hydroxyprogesterone, 3ß, 19-dihydroxy-pregn-5-en-20-one 3-acetate and pregn-5-ene-3ß, 19, 20ß-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19-hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20-dione as substrate, the transformation was more complex and many products were formed.

Appl Environ Microbiol. 1970 July; 20(1): 23-25
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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