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Appl Environ Microbiol. 1970 September; 20(3): 465-468
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Anticomplementary, Anticoagulatory, and Serum-Protein Precipitating Activity of Sodium Polyanetholsulfonate

Departments of Microbiology and Pathology, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103

ABSTRACT

Sodium polyanetholsulfonate (SPS) at 7.8 µg/ml completely abolished complement-mediated hemolysis of 1:10 diluted fresh guinea pig and human serum; at least twice as much SPS was required to reduce complement activity in 1:2 diluted human serum. The coagulation of 90 and 20% human blood was inhibited by 250 and 125 µg of SPS per ml, respectively. When added to fresh human serum, SPS precipitated beta 1C-globulin (C3), C4, beta lipoproteins, immunoglobulin IgG, IgM, and IgA, though incompletely.

¹ Present address: Department of Otolaryngology, West Virginia Medical Center, Morgantown, W.Va. 25605.