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Appl Environ Microbiol. 1970 October; 20(4): 536-538
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Characteristics of Growth Inhibition of Lactobacillus casei by 4-Nitroquinoline-n-Oxide

Department of Chemistry, Baylor University, Waco, Texas 76703

ABSTRACT

The bacteriostatic action of 4-nitroquinoline-n-oxide (4-NQO) for Lactobacillus casei is substantially reversed by D-and L-cysteine, glutathione, and 2,2-dihydroxy-1,4-dithiolbutane (dithioerythritol). The action appears to involve a chemical reaction between carbon atom 4 of 4-NQO and nucleophilic centers, such as -SH groups, located on essential cell constituents. The evidence presented indicates that the protective effect of D- and L-cysteine, glutathione, and dithioerythritol against the action involves reactions between 4-NQO and -SH compounds.