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Appl Environ Microbiol. 1970 October; 20(4): 551-554
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Enhancement of Friend Leukemia Virus Infection in Mice by Guaroa Virus: Quantitation and Action of Various Oncogenic and Nononcogenic Viruses

Microbiological Associates, Inc., Walkersville, Maryland 21793
Viral Leukemia and Lymphoma Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

Previous studies have indicated that Guaroa virus (GV), an arbovirus, enhanced the replication of Friend leukemia virus (FLV) in mice. To study further the interaction of GV and FLV, different levels of FLV activity were inoculated into mice. At a level of activity capable of producing limited splenic response, coinfection with GV resulted in a marked increase in spleen-foci activity, mean spleen weight, and amount of infectious virus recoverable from plasma and spleen of dually infected mice. Various oncogenic and nononcogenic viruses were also tested for their ability to enhance FLV infection.