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Appl Environ Microbiol. 1970 October; 20(4): 630-632
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Susceptibility of Pseudomonas aeruginosa to Carbenicillin

Department of Pathology, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103

ABSTRACT

Ninety clinical isolates of Pseudomonas aeruginosa were examined for susceptibility to carbenicillin by the broth dilution and disc diffusion methods. Inhibition zone diameters varied at given minimal inhibitory concentration levels of the antibiotic. Nevertheless, the results obtained allowed the proposal of the following tentative criteria for the interpretation of inhibition zones. Pseudomonadaceae yielding zones of inhibition measuring at least 10 and 16 mm in diameter around 25-and 100-µg discs, respectively, are sensitive to this antibiotic when examined by the standardized Bauer-Kirby method of disc susceptibility testing. Isolates characterized by zones of less than 100 mm in diameter around 25-µg discs should be tested with 100-µg discs before they are reported as sensitive or resistant to carbenicillin.