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Appl Environ Microbiol. 1970 November; 20(5): 704-709
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Comparative Study of ¹⁴C-Labeled Purified Protein Derivative from Various Mycobacteria

II. Skin Cross-Reactivity in Sensitized Guinea Pigs

Connaught Medical Research Laboratories, University of Toronto, Toronto, Ontario, Canada

ABSTRACT

A study on skin cross-reactivity between stabilized ¹⁴C-labeled mycobacterial antigens, namely tuberculin purified protein derivative (PPD; from Mycobacterium tuberculosis), PPD-A (M. avium), PPD-Y (M. kansasii), PPD-G (M. scrofulaceum), PPD-B (M. intracellulare), and PPD-F (M. fortuitum), has been carried out in groups of guinea pigs sensitized with one of the following heat-killed mycobacteria: M. tuberculosis, M. avium, M. kansasii, M. scrofulaceum, M. intracellulare, or M. fortuitum. For each type of sensitization, the average response for the corresponding PPD antigen was higher than the average response for any of the other antigens. However, the responses to the heterologous PPD antigens were not necessarily significantly different among themselves, and the significant differences of the heterologous PPD antigens were distributed differently according to the type of sensitization. Therefore, ¹⁴C-PPD antigens skin cross-reacted in guinea pigs essentially in the same manner as reported by others for nonradioactive PPD antigens.