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Appl Environ Microbiol. 1970 November; 20(5): 734-736
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Paper Chromatographic Techniques for the Determination of Cephalothin and Desacetylcephalothin in Body Fluids

Marvin M. Hoehn, Hubert W. Murphy, Charles T. Pugh and Norman E. Davis

Lilly Research Laboratories, Indianapolis, Indiana 46206

ABSTRACT

Paper chromatographic procedures may be used to detect cephalothin and its metabolite desacetylcephalothin in urine, plasma, synovial fluid, and cerebrospinal fluid. Protein-bound antibiotics are released from plasma, cerebrospinal fluid, and synovial fluid by dilution with an equal volume of dimethylformamide. Data are presented on the sample preparation, paper chromatographic system, and other specific techniques.

Appl Environ Microbiol. 1970 November; 20(5): 734-736
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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Copyright © 1970 by the American Society for Microbiology. All rights reserved.