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Appl Environ Microbiol. 1970 December; 20(6): 875-879
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Microbial Aromatization of Steroids into Equilin

S. N. Sehgal and Claude Vézina

Department of Microbiology, Ayerst Research Laboratories, Montreal, Quebec, Canada

ABSTRACT

This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.

Appl Environ Microbiol. 1970 December; 20(6): 875-879
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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