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Appl Environ Microbiol. 1970 December; 20(6): 910-912
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Inhibition of Nucleic Acid and Protein Synthesis in Mouse Spleen Cells In Vitro by Azathioprine

Grace Y. Chan and Robert L. Stone

Biological Research Division, Eli Lilly Research Laboratories, Indianapolis, Indiana 46206

ABSTRACT

The effect of azathioprine on macromolecular biosynthesis was studied in mouse spleen cells cultured in vitro. The rate of incorporation of 3H-thymidine, 3H-uridine, and 14C-leucine into acid-insoluble material was used to measure deoxyribonucleic acid, ribonucleic acid, and protein synthesis. Results indicate that azathioprine inhibited nucleic acid and protein synthesis at levels which did not decrease cell viability.

Appl Environ Microbiol. 1970 December; 20(6): 910-912
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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Copyright © 1970 by the American Society for Microbiology. All rights reserved.