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Appl Environ Microbiol. 1971 February; 21(2): 209-216
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Laminar Airflow Protection In Bone Marrow Transplantation

Claus O. Solberg1, John M. Matsen, Donald Vesley, Donald J. Wheeler, Robert A. Good and Hilaire J. Meuwissen

School of Public Health, Department of Laboratory Medicine, and the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

A laminar airflow room was used to provide a low-pathogen environment for a child with lymphopenic immune deficiency transplanted with paternal bone marrow. Comparison of flora from the patient, personnel, and the environment indicated that no colonization with exogenous organisms occurred in the patient during the 45-day period of study. The number of organisms recovered from the laminar airflow room was exceedingly small. Conventional hospital isolation rooms contained more bacteria and fungi than the laminar airflow room, even when strict aseptic procedures were followed in the former. Patients with lymphopenic immune deficiency and agranulocytosis admitted to conventional isolation rooms were colonized with exogenous organisms within 1 week. Each developed infection with these strains, and one patient died. Laminar airflow isolation seems at present the best means to prevent exogenous infection during hospitalization of patients with lymphopenic and other severe immune-deficiency diseases and may be essential when bone marrow transplantation is performed to treat their immunological defect.

FOOTNOTES

1 Present address: University of Bergen, School of Medicine, Medical Department B, Bergen, Norway.

Appl Environ Microbiol. 1971 February; 21(2): 209-216
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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Copyright © 1971 by the American Society for Microbiology. All rights reserved.