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Appl Environ Microbiol. 1971 February; 21(2): 300-305
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Renal Lysozyme Levels in Animals Developing Proteus mirabilis-Induced Pyelonephritis

W. W. Eudy and S. E. Burrous

Research and Development Department, The Norwich Pharmacal Co., Norwich, New York 13815

ABSTRACT

In animals developing experimentally induced unilateral pyelonephritis, both the infected kidney (IK) and the contralateral noninfected kidney (NIK) showed an immediate increase in renal lysozyme activity of about 5 days' duration after the unilateral injection of viable Proteus mirabilis into the renal cortex. Lysozyme activities of the NIK were consistently higher than those of the IK. This initial increase was followed by a second increase which lasted throughout the period of observation (17 days), and enzyme activities of the NIK were consistently higher than those of the IK. In saline punctured kidneys of control animals, both the saline punctured kidney (SP) and the non-saline punctured kidney (NSP) showed only the immediate increase in renal lysozyme activity, which persisted until the SP was completely healed. These enzyme activities were less than those observed in the infected animals, but the response of the NSP was greater than that of the SP. Trauma not directed to the kidney does not produce a similar response of renal lysozyme. The elevated renal lysozyme of the NIK could not be shown to protect it from bacterial infection.

Appl Environ Microbiol. 1971 February; 21(2): 300-305
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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Copyright © 1971 by the American Society for Microbiology. All rights reserved.