AEM
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peckham, J. C.
Right arrow Articles by Jones, O. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Peckham, J. C.
Right arrow Articles by Jones, O. H., Jr.
Agricola
Right arrow Articles by Peckham, J. C.
Right arrow Articles by Jones, O. H.

 Previous Article  |  Next Article 

Appl Environ Microbiol. 1971 March; 21(3): 492-494
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Acute Toxicity of Ochratoxins A and B in Chicks 1

John C. Peckham, Ben Doupnik Jr. and Oscar H. Jones Jr.

University of Georgia Coastal Plain Experiment Station and Diagnostic and Research Laboratories, College of Veterinary Medicine, University of Georgia, Tifton, Georgia 31794

ABSTRACT

Ochratoxins A and B were given to 1-day-old Babcock B-300 cockerels to evaluate acute toxic effects. Two trials with ochratoxin A gave 7-day oral median lethal dose estimates of 116 µg (3.3 mg/kg) and 135 µg (3.9 mg/kg) per chick. Chicks given daily oral doses of 100 µg of ochratoxin A died on the second day. Single subcutaneous doses of 400 µg of ochratoxin A were also lethal. The 7-day oral median lethal dose of B was estimated at 1,890 µg (54 mg/kg) per chick. Chicks given oral doses of 100 µg of ochratoxin B daily for 10 days survived. Sublethal doses of both ochratoxins A and B resulted in growth suppression which was proportional to the amount of ochratoxin given. Visceral gout was the principal gross finding. Microscopic examinations revealed acute nephrosis, hepatic degeneration or focal necrosis, and enteritis. Suppression of hematopoiesis in the bone marrow and depletion of lymphoid elements from the spleen and bursa of Fabricius were frequently seen. Both ochratoxins appeared to have similar pathological effects. This is the first report on the toxicity of ochratoxin B.

FOOTNOTES

1 Published as University of Georgia Experiment Stations Journal Series paper 893 and Institute of Comparative Medicine manuscript 829.

Appl Environ Microbiol. 1971 March; 21(3): 492-494
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Microbiol. Mol. Biol. Rev. Eukaryot. Cell All ASM Journals

Copyright © 1971 by the American Society for Microbiology. All rights reserved.