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Appl Environ Microbiol. 1971 September; 22(3): 397-400
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Quantitative Nasal Culture: a Tool in Antibiotic Research

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202

ABSTRACT

The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Although in previous studies by others cyclacillin was effective in treating mice infected with penicillin G-resistant staphylococci, in the present studies cyclacillin was not effective in suppressing nasal penicillin G-resistant staphylococci in man at doses which markedly suppressed penicillin G-sensitive organisms.

¹ Present address: Department of Medicine and Microbiology, Baylor College of Medicine, Houston, Tex.