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Appl Environ Microbiol. 1971 September; 22(3): 478-479
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Pigment Production of Cryptococcus neoformans Grown with Extracts of Guizotia abyssinica

Skin and Cancer Hospital, Philadelphia, Pennsylvania 19140
Department of Microbiology, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140

ABSTRACT

Brown pigment(s) formed in Cryptococcus neoformans when grown on media containing extracts of the seeds of Guizotia abyssinica cannot be extracted by common organic solvents or by 6 N HCl or 2 N NaOH. A similar pigmentation was observed in C. neoformans when grown on a medium containing caffeic acid isolated from the hydrolyzed methanol extract of G. abyssinica seeds. Its methyl ester and the diacetate thereof, as well as the following structurally related compounds, 3-hydroxytyramine, 3,4-dihydroxybenzoic acid, 3,4-dihydroxyphenylethanolamine, and 4-hydroxy-3,5-dimethoxycinnamic acid, brought about similar pigmentation. However, 2,4-, 2,5-, 2,6-, and 3,5-dihydroxybenzoic acids, tyrosine, phenylalanine, cinnamic acid, 4-hydroxycinnamic acid, and 4-hydroxy-3-methoxycinnamic acid did not cause coloration in C. neoformans.