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Appl Environ Microbiol. 1971 December; 22(6): 957-962
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effects of Actinobolin on Growth and Some Metabolic Activities of Cariogenic Streptococci In Vitro and In Vivo

Institute of Dental Research, University of Alabama, Birmingham, Alabama 35233
Department of Microbiology, School of Dentistry, University of Alabama, Birmingham, Alabama 35233
Department of Biochemistry, School of Dentistry, University of Alabama, Birmingham, Alabama 35233

ABSTRACT

Actinobolin, a known inhibitor of protein synthesis, has been shown not to interfere selectively with acid production or dextransucrase activity in a cariogenic streptococcus when the antibiotic is added to a concentration of 500 µg/ml. It has also been shown that actinobolin does not alter the total in vivo flora of the oral cavity of the rat when tested in a rat caries model system. A culture of cariogenic streptococci, adapted to in vitro growth in the presence of 1 mg of actinobolin per ml, has also been isolated.