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Appl Environ Microbiol. 1972 January; 23(1): 130-134
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Reproducible Topical Staphylococcal Infection in Rats¹

^a Johnson and Johnson Research, North Brunswick, New Jersey 08903

ABSTRACT

A topical infection model for the study of the effectiveness of antimicrobials was developed. Animals were laparotomized, sutured with braided silk, and inoculated with a strain of Staphylococcus aureus. The test organism was phage typed, and its antibiotic spectrum was determined. Concentrations of bacteria from 5 x 10⁴ to 10⁸ cells per incision produced large body wall stitch abscesses with occasional drainage through the skin. This laparotomy infection is readily reproducible and can be used for evaluation of the ability of topical antimicrobials to prevent S. aureus stitch abscesses.

¹ Presented in part at the 70th Annual Meeting of the American Society for Microbiology, Boston, Mass., 26 April 1 May 1970.