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Appl Environ Microbiol. 1972 January; 23(1): 72-77
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Microbial Degradation of Sterols

William J. Marsheck, Stephen Kraychy and Robert D. Muir

Division of Biological Research, G. D. Searle and Co., Chicago, Illinois 60680
Division of Biochemical Research, G. D. Searle and Co., Chicago, Illinois 60680

ABSTRACT

A process is described for the microbial degradation of cholesterol and plant sterols, to produce androsta-1, 4-diene-3, 17-dione and androst-4-ene-3, 17-dione, by two newly isolated bacteria designated Mycobacterium sp. NRRL B-3683 and Mycobacterium sp. NRRL B-3805. These myocbacteria produce substantial amounts of 17-ketonic compounds without appreciable degradation of the steroid nucleus. No ring degradation inhibitory agents are necessary. The first microbiological production of 20{alpha}-hydroxymethylpregna-1, 4-dien-3-one is also reported.

Appl Environ Microbiol. 1972 January; 23(1): 72-77
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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Copyright © 1972 by the American Society for Microbiology. All rights reserved.