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Appl Environ Microbiol. 1972 May; 23(5): 951-952
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Comparative Immunogenicities of Chikungunya Vaccines Propagated in Monkey Kidney Monolayers and Chick Embryo Suspension Cultures

¹ Department of Biologics Research, Walter Reed Army Institute of Research, Washington, D.C. 20012

ABSTRACT

A comparative study was made of Formalin-inactivated Chikungunya vaccines prepared from the virus propagated in African green monkey kidney monolayers and concentrated chick embryo suspension cultures. The vaccine prepared in the chick embryo suspension cultures was significantly more protective to mice against a live homologous virus challenge and stimulated the production of 4 to 5 times more circulating antibodies than the vaccine prepared with virus grown in African green monkey kidney monolayer cultures.