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Appl Environ Microbiol. 1972 July; 24(1): 91-95
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Chromatography of Venezuelan Equine Encephalomyelitis Virus Strains on Calcium Phosphate

¹ U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

ABSTRACT

Column chromatography of selected Venezuelan equine encephalomyelitis (VEE) viruses on calcium phosphate gel offered a simple and reproducible method for examination of biochemical characteristics and relatedness of strains within the VEE complex. Members of antigenic subgroup I demonstrated a series of elution profiles within a narrow range of 0.22 to 0.25 M phosphate buffer. Members of antigenic subgroups II, III, and IV differed substantially among themselves and viruses of antigenic subgroup I. These differences in elution behavior may contribute to understanding of observed differences in biological behavior and antigenic variation among VEE viruses.