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Appl Environ Microbiol. 1972 November; 24(5): 735-741
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Interferon Production by Human Cells In Vitro

¹ Department of Medical Microbiology, University of California, Davis, California 95616

ABSTRACT

The relative capacity of several types of human cells and tissue to produce interferon was studied. Types of cells and tissue included were fibroblasts from embryos, foreskins, and biopsied skins; amnion cells; peripheral leukocytes; established lymphoid cell lines; established heteroploid cell lines; and chorioamniotic membrane. When Newcastle disease virus was used as the inducer, fibroblasts and amnion cells produced more interferon per 10⁶ cells than leukocytes, lymphoid cells, and heteroploid cells. Only minor variations in interferon-producing capacity were observed among fibroblasts from 36 persons. Culture passage level, cell concentration, and inducer were factors that significantly affected interferon production.