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Appl Environ Microbiol. 1972 November; 24(5): 841-843
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Isolation of a New Soluble Antigen from the Yeast Phase of Histoplasma capsulatum

Research and Development Unit, Biological Reagents Section and Fungus Immunology Unit, Mycology Section, Center for Disease Control, Health Services and Mental Health Administration, Atlanta, Georgia 30333

ABSTRACT

A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum. This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. The reactivities of the two types of antigens with homologous sera were essentially the same.