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Appl Environ Microbiol. 1973 January; 25(1): 103-106
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Competitive Inhibition for Amino Acid Uptake by the Indigenous Microflora of Upper Klamath Lake¹

Department of Microbiology, Oregon State University, Corvallis, Oregon 97331
Department of Oceanography, Oregon State University, Corvallis, Oregon 97331

ABSTRACT

The uptake of a specific ¹⁴C-amino acid by the heterotrophic microorganisms in the epilimnion of an eutrophic lake was influenced by the presence of other amino acids. The effect of unlabeled serine on ¹⁴C-glycine uptake was shown to be caused by competitive inhibition, which changed the interpretation of the kinetic parameters, the turnover time, T_t, and the sum of a transport constant, (K_t + (S_n), and the natural substrate concentration. The maximum velocity of uptake, V_max, is unaffected by the competitive inhibition.

² Present address: Institute of Animal Resource Ecology, University of British Columbia, Vancouver 8, B. C., Canada.

¹ This paper was published as technical paper no. 3464, Oregon Agricultural Experiment Station.