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Appl Environ Microbiol. 1974 February; 27(2): 423-424
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

In Vitro Metabolism of T-2 Toxin

Robert A. Ellison and Frank N. Kotsonis

School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53706

ABSTRACT

Incubation of T-2 toxin with the 9,000 x g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver. HT-2 toxin was not produced when human plasma was the incubating medium nor was it produced by treatment of T-2 toxin with simulated gastric juice. T-2 toxin was stable in gastric juice for at least 1 h.

Appl Environ Microbiol. 1974 February; 27(2): 423-424
Copyright © 1974 American Society for Microbiology. All Rights Reserved.





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Copyright © 1974 by the American Society for Microbiology. All rights reserved.